MEDICINES

Seizures

Seizure symptoms can vary widely. Some people with epilepsy simply stare blankly for a few seconds during a focal or generalized seizure, while others repeatedly twitch their arms or legs. Having a single seizure doesn’t mean you have epilepsy. At least two seizures without a known trigger (unprovoked seizures) that happen at least 24 hours apart are generally required for an epilepsy diagnosis.

Treatment with medications or sometimes surgery can control seizures for the majority of people with epilepsy. Some people require lifelong treatment to control seizures, but for others, the seizures eventually go away. Some children with epilepsy may outgrow the condition with age.

Symptoms of Seizures

Because epilepsy is caused by abnormal activity in the brain, seizures can affect any process your brain coordinates. Seizure signs and symptoms may include:

Temporary confusion

A staring spell

Stiff muscles

Uncontrollable jerking movements of the arms and legs

Loss of consciousness or awareness

Psychological symptoms such as fear, anxiety or deja vu

Symptoms vary depending on the type of seizure. In most cases, a person with epilepsy will tend to have the same type of seizure each time, so the symptoms will be similar from episode to episode.

Doctors generally classify seizures as either focal or generalized, based on how and where the abnormal brain activity begins.

Focal seizures

When seizures appear to result from abnormal activity in just one area of your brain, they’re called focal seizures. These seizures fall into two categories:

Focal seizures without loss of consciousness.

Once called simple partial seizures, these seizures don’t cause a loss of consciousness. They may alter emotions or change the way things look, smell, feel, taste or sound. Some people experience deja vu. This type of seizure may also result in involuntary jerking of one body part, such as an arm or leg, and spontaneous sensory symptoms such as tingling, dizziness and flashing lights.

Focal seizures with impaired awareness.

Once called complex partial seizures, these seizures involve a change or loss of consciousness or awareness. This type of seizure may seem like being in a dream. During a focal seizure with impaired awareness, you may stare into space and not respond normally to your environment or perform repetitive movements, such as hand rubbing, chewing, swallowing or walking in circles.

Symptoms of focal seizures may be confused with other neurological disorders, such as migraine, narcolepsy or mental illness. A thorough examination and testing are needed to distinguish epilepsy from other disorders.

Generalized seizures

Seizures that appear to involve all areas of the brain are called generalized seizures. Six types of generalized seizures exist.

Absence seizures:

Absence seizures, previously known as petit mal seizures, typically occur in children. They’re characterized by staring into space with or without subtle body movements such as eye blinking or lip smacking and only last between 5-10 seconds. These seizures may occur in clusters, happening as often as 100 times per day, and cause a brief loss of awareness.

Tonic seizures.

Tonic seizures cause stiff muscles and may affect consciousness. These seizures usually affect muscles in your back, arms and legs and may cause you to fall to the ground.

Atonic seizures.

Atonic seizures, also known as drop seizures, cause a loss of muscle control. Since this most often affects the legs, it often causes you to suddenly collapse or fall down.

Clonic seizures.

Clonic seizures are associated with repeated or rhythmic, jerking muscle movements. These seizures usually affect the neck, face and arms.

Myoclonic seizures.

Myoclonic seizures usually appear as sudden brief jerks or twitches and usually affect the upper body, arms and legs.

Tonic-clonic seizures.

Tonic-clonic seizures, previously known as grand mal seizures, are the most dramatic type of epileptic seizure. They can cause an abrupt loss of consciousness and body stiffening, twitching and shaking. They sometimes cause loss of bladder control or biting your tongue.

When to see a doctor

Seek immediate medical help if any of the following occurs:

The seizure lasts more than five minutes.

Breathing or consciousness doesn’t return after the seizure stops.

A second seizure follows immediately.

You have a high fever.

You’re pregnant.

You have diabetes.

You’ve injured yourself during the seizure.

You continue to have seizures even though you’ve been taking anti-seizure medication.

If you experience a seizure for the first time, seek medical advice.

Insulin Therapy

Insulin is a hormone produced by the pancreas to help the body use and store glucose. Glucose is a source of fuel for the body.

With diabetes, the body cannot regulate the amount of glucose in the blood (called glycemia or blood sugar). Insulin therapy can help some people with diabetes maintain their blood sugar levels.

Information

Carbohydrates from food are broken down into glucose and other sugars. Glucose is absorbed from the digestive tract into the bloodstream. Insulin lowers blood sugar by allowing it to move from the bloodstream into muscle, fat, and other cells, where it can be stored or used as fuel. Insulin also tells the liver how much glucose to produce when you are fasting (have not had a recent meal).
People with diabetes have high blood sugar because their body does not make enough insulin or because their body does not respond to insulin properly.

 

With type 1 diabetes the pancreas produces little to no insulin.

With type 2 diabetes the fat, liver, and muscle cells do not respond correctly to insulin. This is called insulin resistance. Over time, the pancreas stops making as much insulin.

Insulin Doses and Types

Insulin therapy replaces the insulin the body would normally make. People with type 1 diabetes must take insulin every day.

People with type 2 diabetes need to take insulin when other treatments and medicines fail to control blood sugar levels.

Insulin doses are given in two main ways

Basal dose – provides a steady amount of insulin delivered all day and night. This helps maintain blood glucose levels by controlling how much glucose the liver releases (mainly at night when the time between meals is longer).

Bolus dose – provides a dose of insulin at meals to help move absorbed sugar from the blood into muscle and fat. Bolus doses can also help correct blood sugar when it gets too high. Bolus doses are also called nutritional or meal-time doses.

There are several types of insulin available. Insulin types are based on :

Onset – how quickly it starts working after injection

Peak – time when the dose is the strongest and most effective

Duration – total time the insulin dose stays in the bloodstream and lowers blood sugar

Types of insulin:

Rapid-acting or fast-acting insulin starts working within 15 minutes, peaks in 1 hour, and lasts for 4 hours. It is taken right before or just after meals and snacks. It is often used with longer-acting insulin.

Regular or short-acting insulin reaches the bloodstream 30 minutes after use, peaks within 2 to 3 hours, and lasts 3 to 6 hours. This is taken a half-hour before meals and snacks. It is often used with longer-acting insulin.

Intermediate-acting insulin starts working within 2 to 4 hours, peaks in 4 to 12 hours, and lasts 12 to 18 hours. This is taken mostly either twice a day or once at bedtime.

Long-acting insulin starts to work a few hours after injection and works for about 24 hours, sometimes longer. It helps control glucose throughout the day. It is often combined with rapid- or short-acting insulin as needed.

Premixed or mixed insulin is a combination of 2 different types of insulin. It has both a basal and bolus dose to control glucose after meals and throughout the day.

Inhaled insulin is a rapid-acting breathable insulin powder that starts working within 15 minutes of use. It is used just before meals.

One or more types of insulin may be used together to help control your blood sugar. You also may use insulin along with other diabetes medicines. Your health care provider will work with you to find the right combination of medications for you.

Your provider will tell when and how often you need to take insulin.

Your dosing schedule may depend on:

Your weight

Type of insulin you take

How much and what you eat

Level of physical activity

Your blood sugar level

Other health conditions

Your provider can calculate the insulin dose for you. Your provider will also tell you how and when to check your blood sugar and time your doses during the day and night.

Ways to Take Insulin

Insulin cannot be taken by mouth because stomach acid destroys insulin. It is most often injected under the skin into fatty tissue. There are different insulin delivery methods available:

Insulin syringe – insulin is drawn from a vial into a syringe. Using the needle, you inject the insulin under the skin.

Insulin pump – a small machine worn on the body pumps insulin under the skin throughout the day. A small tube connects the pump to a small needle inserted into the skin.

Insulin pen – disposable insulin pens have prefilled insulin delivered under the skin using a replaceable needle.

Inhaler – a small device you use to inhale insulin powder through your mouth. It is used at the start of meals.

Injection port – a short tube is inserted into the tissue under the skin. The port containing tube is adhered to skin using adhesive tape. Fast-acting insulin is injected into the tube using a syringe or pen. This allows you to use the same injection site for 3 days before rotating to a new site.

You can talk with your health care provider about your preferences when deciding on an insulin delivery method.

Insulin is injected into these sites on the body:

Abdomen

Upper arm

Thighs

Hips

Your provider will teach you how to give an insulin injection or use an insulin pump or other device. It is important not to always use the same site as this can decrease how effective the insulin is for you.

Points to Remember

You need to know how to adjust the amount of insulin you are taking:

When you exercise

When you are sick

When you will be eating more or less food

When you are traveling

Before and after surgery

When to Call the Doctor

If you are taking insulin, contact your provider if:

You think you may need to change your insulin routine

You have any problems taking insulin

Your blood sugar is too high or too low and you don’t understand why

Depression

Depression may be described as feeling sad, blue, unhappy, miserable, or down in the dumps. Most of us feel this way at one time or another for short periods.

Clinical depression is a mood disorder in which feelings of sadness, loss, anger, or frustration interfere with everyday life for weeks or more.

Considerations of Depression

Depression can occur in people of all ages:

Adults, Teenagers ,Older adults

Symptoms of depression include:

Low mood or irritable mood most of the time

Trouble sleeping or sleeping too much

A big change in appetite, often with weight gain or loss

Tiredness and lack of energy

Feelings of worthlessness, self-hate, and guilt

Difficulty concentrating

Slow or fast movements

Lack of activity and avoiding usual activities

Feeling hopeless or helpless

Repeated thoughts of death or suicide

Lack of pleasure in activities you usually enjoy, including sex

Remember that children may have different symptoms than adults. Watch for changes in schoolwork, sleep, and behavior.

If you wonder whether your child might be depressed, talk with your health care provider. Your provider can help you learn how to help your child with depression.

Types of Depression

Major depression: It occurs when feelings of sadness, loss, anger, or frustration interfere with daily life for 2 weeks or longer periods of time.

Persistent depressive disorder.: This is a depressed mood that lasts 2 years. Over that length of time, you may have periods of major depression, with times when your symptoms are milder.

Postpartum depression: Many women feel somewhat down after having a baby. However, true postpartum depression is more severe and includes the symptoms of major depression.

Premenstrual dysphoric disorder (PMDD).: Symptoms of depression occur 1 week before your period and disappear after you menstruate.

Seasonal affective disorder (SAD).: This occurs most often during fall and winter, and disappears during spring and summer. It is most likely due to a lack of sunlight.

Major depression with psychotic features: This occurs when a person has depression and loss of touch with reality (psychosis).

Bipolar disorder occurs when depression alternates with mania (formerly called manic depression). Bipolar disorder has depression as one of its symptoms, but it is a different type of mental illness.

Causes of Depression.

Depression often runs in families. This may be due to your genes, behaviors you learn at home, or your environment. Depression may be triggered by stressful or unhappy life events. Often, it is a combination of these things.

Many factors can bring on depression: 

Alcohol or drug use

Medical conditions, such as cancer or long-term (chronic) pain

Stressful life events, such as job loss, divorce, or death of a spouse or other family member

Social isolation (a common cause of depression in older adults)

When to Contact a Medical Professional

Call your provider if:

You hear voices that are not there.

You cry often without cause.

Your depression has affected your work, school, or family life for longer than 2 weeks.

You have three or more symptoms of depression.

You think one of your current medicines may be making you feel depressed.

DO NOT change or stop taking any medicines without talking to your provider.If you think your child or teen may be depressed!

You should also call your provider if:

You think you should cut back on drinking alcohol

A family member or friend has asked you to cut back on drinking alcohol

You feel guilty about the amount of alcohol you drink

You drink alcohol first thing in the morning

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